Industry Review of Cell Separation and Product Harvesting Methods
| Autor: | John W. Armando, Jörg Thömmes, Matthew Westoby, John Pieracci |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0106 biological sciences
0301 basic medicine Chemistry business.industry Therapeutic protein 01 natural sciences 03 medical and health sciences 030104 developmental biology Cell harvest 010608 biotechnology Yield (chemistry) Product (mathematics) Cell separation Process engineering business Host (network) Production system |
| DOI: | 10.1016/b978-0-08-100623-8.00009-8 |
| Popis: | Once a therapeutic protein has been produced by a chosen production system, the product must be separated and recovered from the host system. Cell harvest and recovery serve this function by removing or isolating host cells so that the product can be recovered from the host system, and the product stream can be clarified prior to the purification process. These process steps are the link between the synthesis and the purification of the therapeutic products. They are critical to yield the product in its native form from the production system and require careful optimization. |
| Databáze: | OpenAIRE |
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