| Autor: |
David Lydall, R. J. Knox, M. F. Pera, John J. Roberts, F. Friedlos |
| Rok vydání: |
1988 |
| Předmět: |
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| Zdroj: |
Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy ISBN: 9781461289678 |
| DOI: |
10.1007/978-1-4613-1717-3_2 |
| Popis: |
Evidence that the cytotoxicity of platinum compounds is due to their reactions with DNA came from studies of these reactions with the DNA of cultured cells and from studies of the responses of prokaryotic and eukaryotic cells to modifications of their DNA by these agents (1,2). However while such data adequately explain the cytotoxicity of platinum compounds in vitro, evidence implicating reactions with DNA in the anti-tumour effects these compounds is limited. Important questions therefore are whether cells differ in their responses to platinum compounds and whether such differences are a function of the extent of drug uptake and binding of platinum to macromolecules? Alternatively, do cells differ in their sensitivities to a given amount of DNA bound platinum and, if so, is this due to differences in their abilities to remove platinum adducts from their DNA by various excision repair processes or to differences in their abilities to tolerate lesions in their DNA when such damaged DNA undergoes replication? |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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