T and B cells and cell-mediated immunity in mycosis fungoides

Autor: John P. Kinney, Barbro C. Nordqvist
Rok vydání: 1976
Předmět:
Zdroj: Cancer. 37:714-718
ISSN: 1097-0142
0008-543X
DOI: 10.1002/1097-0142(197602)37:2<714::aid-cncr2820370216>3.0.co;2-q
Popis: T anb B cells in peripheral blood were evaluated in 13 patients with mycosis fungoides (MF) and in two patients with Sezary's syndrome. T cells were identified by their capacity to bind sheep red blood cells to their surfaces and the B cells were identified by the presence of surface immunoglobulins in immunofluorescence assay. Seven patients with MF and two with Sezary's syndrome were shown to have T-cell values below normal and elevated levels of null cells, i.e., cells with markers for neither T nor B cells. Low T-cell values and elevated Null-cell values were found predominantly in patients with advanced mycosis fungoides (stages III-IV). Furthermore, these patients had impaired cell-mediated immunity, as shown by in vivo skin testing with recall antigens and attempts at sensitization to dinitrochlorobenzene.
Databáze: OpenAIRE
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