| Popis: |
Publisher Summary This chapter provides an overview of the behavioral and morphological effects of the depletion of the mesocortical DA (dopaminergic) system, either in early life or in adulthood. It also explores when and where the DA-containing fibers arrive in the prefrontal cortex (PFC) and at what age the adult innervation pattern is accomplished. The pre- and postnatal development of the DA innervation in the PFC is reviewed in the chapter. It also describes the procedures to lesion the DA fibers as early and selectively as possible. After the completion of behavioral experiments, different parameters of PFC development are measured and compared in the chapter. Neonatal depletion of DA and 5HT (serotonin) from the developing PFC, prior to synaptogenesis, has best effects on the gross features of cortical morphology, such as lamination, cortical thickness, and volume. The results of biochemical experiments show that the damaged DA system can compensate for lesion-induced loss of DA containing terminals by increasing the DA metabolism of the remaining terminals. |
