Synthesis of the Nonpeptide Renin Inhibitor A-68064 and the ACE Inhibitor Methyl Enalaprilat from (5S)-2,3,5,6-Tetrahydro-5-alkyl-N-(tert-butyloxycarbonyl-4H-1,4-oxazine-2-ones

Autor:	Stephen Condon, William R. Baker
Rok vydání:	1992
Předmět:	chemistry.chemical_classification biology Enalaprilat medicine.drug_class Chemistry Stereochemistry Organic Chemistry Carboxamide Biochemistry Renin inhibitor Enzyme inhibitor Drug Discovery Renin–angiotensin system ACE inhibitor medicine biology.protein Lactone Alkyl medicine.drug
Zdroj:	Tetrahedron Letters. 33:1577-1580
ISSN:	0040-4039
Popis:	The nonpeptide renin inhibitor, A-68064, and the ACE inhibitor methyl enalaprilat were synthesized from (5S) 2,3,5,6-tetrahydro-5-benzyl(butyl)-N-(tert-butoxycarbonyl)-4H-1,4-oxazine-2-ones 7a and 7b, and (5S) 2,3,5,6-tetrahydro-5-methyl-N-(tert-butoxycarbonyl)-4H-1,4-oxazine-2-one 12, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cc64c8f45dd426cc2705d7aa95dbe592 https://doi.org/10.1016/s0040-4039(00)91678-2 Zobrazit plný text záznamu