Abstract TMP19: Intravenous Recombinant Tissue-type Plasminogen Activator Use in Young Adults With Acute Ischemic Stroke
| Autor: | Lee H. Schwamm, Ronald A Matsouaka, Gregg Fonarow, Ying Xian, Deepak L. Bhatt, Eric E. Smith, Jodi A. Dodds, Shubin Sheng, Eric D. Peterson |
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| Rok vydání: | 2017 |
| Předmět: |
Advanced and Specialized Nursing
medicine.medical_specialty business.industry medicine.medical_treatment Thrombolysis medicine.disease law.invention law Internal medicine Ischemic stroke medicine Recombinant DNA Tissue type Neurology (clinical) Young adult Cardiology and Cardiovascular Medicine Intensive care medicine business Plasminogen activator Stroke Acute ischemic stroke |
| Zdroj: | Stroke. 48 |
| ISSN: | 1524-4628 0039-2499 |
| Popis: | Background: Intravenous recombinant tissue-type plasminogen activator (rt-PA) administration improves outcomes in acute ischemic stroke. However, young patients ( Methods: We analyzed data from the large national Get With The Guidelines–Stroke registry for acute ischemic stroke patients hospitalized between January 2009 and September 2015. Multivariable models with generalized estimating equations (GEE) were used to test for differences between younger (age 18-40) and older (age > 40) acute ischemic stroke patients, controlling for patient and hospital characteristics including stroke severity. Results: Of 1,320,965 AIS patients admitted to participating hospitals, 2.3% (30,448) were aged 18-40. Among these patients, 12.5% received rt-PA versus 8.8% of those aged >40 (p Conclusions: Young acute ischemic stroke patients did not receive rt-PA treatment at lower rates than older patients. Outcomes were better and the rate of symptomatic intracranial hemorrhage was lower in the young patients. However, younger patients had significantly longer door-to-CT and DTN times, providing an opportunity to improve the care of these patients. |
| Databáze: | OpenAIRE |
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