Cholin-PET/CT zur Bildgebung des Prostatakarzinoms
| Autor: | Bernd J. Krause, Michael Souvatzoglou, Sarah M. Schwarzenböck, U. Treiber |
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| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Der Nuklearmediziner. 33:181-186 |
| ISSN: | 1439-5800 0723-7065 |
| DOI: | 10.1055/s-0030-1254161 |
| Popis: | PET and PET/CT using [ 11 C]- and [ 18 F]-labelled choline derivatives are increasingly being used for imaging of prostate cancer. The value of PET and PET/CT with [ 11 C]- and [ 18 F]-labelled choline derivates in biochemical recurrence of prostate cancer has been examined in many studies and demonstrates an increasing importance. Primary prostate cancer can be detected with moderate sensitivity using PET and PET/CT using [ 11 C]- and [ 18 F]-labelled choline derivatives - the differentiation between benign prostatic hyperplasia, prostatitis or high-grade intraepithelial neoplasia (HGPIN) is not always possible. At the present time [ 11 C]choline PET/CT is not recommended in the primary setting but may be utilized in clinically suspected prostate cancer with repeatedly negative prostate biopsies, in preparation of a focused re-biopsy. Promising results have been obtained for the use of PET and PET/CT with [ 11 C]- and [ 18 F]-labelled choline derivates in patients with biochemical recurrence. The detection rate of choline PET and PET/CT for local, regional, and distant recurrence in patients with a biochemical recurrence shows a linear correlation with PSA values at the time of imaging and reaches about 75% in patients with PSA >3 ng/mL. At PSA values below 1 ng/mL, the recurrence can be diagnosed with choline PET/CT in approximately 1/3 of the patients. PET and PET/CT with [ 11 C]- and [ 18 F]choline derivates can be helpful for choosing a therapeutic strategy in the sense of an individualized treatment: since an early diagnosis of recurrence is crucial to the choice of optimal treatment. The localization of the site of recurrence - local recurrence, lymph node metastasis or systemic dissemination - has important influence on the therapy regimen. |
| Databáze: | OpenAIRE |
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