Development of a Robust Protocol for the Determination of Weak Acids’ pKa Values in DMSO

Autor:	Sebastian T. Jung, Joachim Podlech
Rok vydání:	2020
Předmět:	Analyte Chromatography 010405 organic chemistry Chemistry Potassium Organic Chemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Deprotonation Titration Ammonium chloride
Zdroj:	The Journal of Organic Chemistry. 85:10951-10957
ISSN:	1520-6904 0022-3263
DOI:	10.1021/acs.joc.0c00909
Popis:	Two methods for the determination of pKa values of weak acids are described, a direct titration with dimsyl potassium in the presence of an indicator and a back-titration in which an analyte/indicator mixture is deprotonated and then titrated with ammonium chloride. Both methods have been validated by measuring pKa values of compounds, for which values had been determined previously. The back-titration method was applied to measure pKa values of two 1,3-dithiane-derived bissulfoxides and a monosulfone.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cc57075ae51a645473e435cd8f754062 https://doi.org/10.1021/acs.joc.0c00909 Zobrazit plný text záznamu