Enhanced colonic carcinogenesis with azoxymethane in rats after pancreaticobiliary diversion to mid small bowel

Autor:	Robin C. N. Williamson, Frederick L. R. Bauer, John B. Watkins, Jeffrey S. Ross, Ronald A. Malt
Rok vydání:	1979
Předmět:	medicine.medical_specialty Hepatology business.industry Azoxymethane Intestinal Neoplasm Gastroenterology Hyperplasia medicine.disease Colon carcinogenesis chemistry.chemical_compound Biliary excretion chemistry Internal medicine Medicine business human activities
Zdroj:	Gastroenterology. 76:1386-1392
ISSN:	0016-5085
DOI:	10.1016/0016-5085(79)90406-2
Popis:	Since biliary excretion of metabolites might determine the pattern of intestinal neoplasms induced by azoxymethane, the number and distribution of tumors were studied in rats after pancreaticobiliary diversion to the mid small bowel. Pancreaticobiliary diversion was performed either immediately before the first of 16 weekly injections of azoxymethane or 10 days after the last. Seven months after pancreaticobiliary diversion, persistent ileal hyperplasia was manifested by higher levels of mucosal RNA and DNA compared with controls (34–102%: P P P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cc54b8af2f1cb1a53bee88fcc229fe01 https://doi.org/10.1016/0016-5085(79)90406-2 Zobrazit plný text záznamu