Synthesis of flavone-8-carboxylic acid analogues as potential antitumor agents

Autor:	RK Johnson, S. L. Fisher-Shore, C. Keane, C De Witt Blanton, FL McCabe, S. J. Cutler, F. M. El-Kabbani
Rok vydání:	1993
Předmět:	Pharmacology chemistry.chemical_classification Flavone acetic acid Carboxylic acid Organic Chemistry Flavonoid Biological activity General Medicine In vitro chemistry.chemical_compound chemistry Biochemistry In vivo Furan Drug Discovery Cyanohydrin
Zdroj:	European Journal of Medicinal Chemistry. 28:407-414
ISSN:	0223-5234
DOI:	10.1016/0223-5234(93)90127-z
Popis:	Furan o-aminonitriles may be utilized as precursors in the synthesis of flavone-8-carboxylic acids. Some results from in vivo evaluation against P388 leukemia, colon carcinoma 38, and B16 melanoma models suggest that selected examples of the acids are potentially as effective as the antitumor compound, flavone acetic acid. The flavone-8-carboxylic acids did not exhibit significant activity against an in vitro HIV screen or an in vitro antitumor screen consisting of a cell panel of 60 lines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cc4a2dbe86b7c63fc37c36792cc31d9f https://doi.org/10.1016/0223-5234(93)90127-z Zobrazit plný text záznamu