Reactions of octafluoroacridone and related compounds

Autor:	J. Colin Tatlow, Alan E. Pedler, David M. Owen
Rok vydání:	1975
Předmět:	Substitution reaction Hydrolysis chemistry.chemical_compound Chemistry Organic chemistry Protonation Hydrogen atom Methoxide Ring (chemistry) Medicinal chemistry Demethylation Ion
Zdroj:	Journal of the Chemical Society, Perkin Transactions 1. :1380
ISSN:	1364-5463 0300-922X
DOI:	10.1039/p19750001380
Popis:	A new route to polyfluoroacridones is described and the substitution reactions of octafluoroacridone with methoxide ion are discussed, the position of substitution being confirmed by alternative synthesis from an amino-methoxy-octafluorobenzophenone. From octafluoroacridone was prepared 9-chloro-octafluoroacridine, but not nonafluoroacridine, owing to its ready hydrolysis. Polyfluoroacridones give stable sodium salts, isolable in crystalline form.Ready demethylation of methyl polyfluoroaryl ethers occurred with concentrated sulphuric acid when a carboxy-group or hydrogen atom was para to the methoxy-group; this is explained in terms of protonation of the para ring carbon atom.
Databáze:	OpenAIRE
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