| Autor: |
Lucy A. Carver, Jan E. Schnitzer |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Cancer Drug Discovery and Development ISBN: 9781588294258 |
| DOI: |
10.1385/1-59259-893-5:151 |
| Popis: |
The analytical power and throughput of current genomic and proteomic techniques is unparalleled in the history of medical research. Yet, directly and specifically targeting solid tumors in vivo remains a long-sought yet elusive goal of molecular medicine that should benefit both therapy and diagnostic imaging of cancer. The staggering molecular complexity of solid tumors and other tissues of the body as well as the in vivo inaccessibility of tumor cells inside the neoplastic tissue limits the ability of global genomic and proteomic analysis to discover key targets for directing tumor-specific delivery of many therapies and imaging agents in vivo. The dilemma in target discovery today has become identifying which few of the many potential targets identified by high-throughput screening are the most meaningful in targeting, imaging, and treating disease. Thus, reducing data complexity to a manageable subset of candidate targets is clearly desired but requires new analytical paradigms for discovery and validation that define and utilize key biological questions to focus the power of global identification technologies. Here, the utility and pitfalls of new technologies developed to address these problems are discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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