Biological end-points for the assessment of the toxicity of the products of combustion of materials
| Autor: | D. G. Farrar, W. A. Galster |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Polymers and Plastics
Injury control Accident prevention Chemistry Metals and Alloys Environmental engineering Poison control General Chemistry Pulp and paper industry Combustion Electronic Optical and Magnetic Materials Combustion products Toxicity Ceramics and Composites Urea formaldehyde foam Douglas fir |
| Zdroj: | Fire and Materials. 4:50-58 |
| ISSN: | 1099-1018 0308-0501 |
| DOI: | 10.1002/fam.810040108 |
| Popis: | The toxicological end-points used in a method for the assessment of the toxicity of combustion products are described. The evaluation considers three areas of toxicological interaction: incapacitation, death, and post-exposure involvement. The model of incapacitation described is the leg-flexion avoidance response of the rat. Additional end-points to assist in the determination of the causality of the observed toxicity are included. The effects of the combustion products of Douglas fir, a phenolic foam, a urea formaldehyde foam and a flexible polyurethane foam on these endpoint are described. The wide range of types of potential toxicities resulting form exposure of animals to the combustion products of materials is discussed. Additionally discussed are the relative merits of the leg-flexion avoidance response as a model of incapacitation. Conclusions as to the important components of a first-tier toxicological evaluation of combustion products are drawn. |
| Databáze: | OpenAIRE |
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