Thymocyte deletion can bias Treg formation toward low-abundance self-peptide
| Autor: | Laura Panarey, Alissa Basehoar, Andrew J. Caton, Soyoung Oh, Malinda Aitken, Cristina Cozzo Picca |
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| Rok vydání: | 2009 |
| Předmět: |
chemistry.chemical_classification
medicine.diagnostic_test Repertoire fungi Immunology T-cell receptor food and beverages FOXP3 hemic and immune systems chemical and pharmacologic phenomena Peptide Biology Clonal deletion Flow cytometry Thymocyte chemistry medicine Immunology and Allergy IL-2 receptor |
| Zdroj: | European Journal of Immunology. 39:3301-3306 |
| ISSN: | 0014-2980 |
| DOI: | 10.1002/eji.200939709 |
| Popis: | Autoreactive CD4+ T cells can undergo deletion and/or become CD25+Foxp3+ Treg as they develop intrathymically, but how these alternative developmental fates are specified based on interactions with self-peptide(s) is not understood. We show here that thymocytes expressing an autoreactive TCR can be subjected to varying degrees of deletion that correlate with the amount of self-peptide. Strikingly, among thymocytes that evade deletion, similar proportions acquire Foxp3 expression. These findings provide evidence that Foxp3+ Treg can develop among members of a cohort of autoreactive thymocytes that have evaded deletion by a self-peptide, and that deletion and Treg formation can act together to bias the Treg repertoire toward low-abundance self-peptide(s). |
| Databáze: | OpenAIRE |
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