Expression of Smad2 and Smad4 in rhesus monkey endometrium during the menstrual cycle and early pregnancy *
| Autor: | Huitu Liu, Cheng Zhu, Hai-Yan Lin, Xuan Zhang, Hongmei Wang, Qinglei Li, Dong-Lin Liu, Juan Wang |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Messenger RNA
medicine.medical_specialty Pregnancy animal structures media_common.quotation_subject Early pregnancy factor In situ hybridization SMAD Biology medicine.disease Endometrium Epithelium medicine.anatomical_structure Endocrinology Internal medicine medicine biology.protein General Materials Science biological phenomena cell phenomena and immunity Menstrual cycle media_common |
| Zdroj: | Progress in Natural Science. 13:584-589 |
| ISSN: | 1745-5391 1002-0071 |
| DOI: | 10.1080/10020070312331344080 |
| Popis: | Expression of Smad2 and Smad4 mRNAs in the endometrium of rhesus monkey on Days 8, 20 and 28 of the normal menstrual cycle and on Days 12, 18 and 26 of early pregnancy was detected using in situ hybridization. The results showed that Smad2 and Smad4 mRNAs were mainly localized in luminal epithelium and glandular epithelium. The expression of Smad2 mRNA in glandular epithelium was sustained at moderate level on Days 8, 20 and 28 of the menstrual cycle, while the expression of Smad4 gradually increased with the menstrual cycle. Both Smad2 and Smad4 mRNAs in functionalis glandular epithelium were expressed at the highest levels on Day 12 of early pregnancy, while in basalis glandular epithelium the most abundant expression of both Smads occurred on Days 12 and 18 of pregnancy. On Day 26, both Smads mRNAs were expressed at the lowest levels either in functionalis or in basalis. The data suggest that the epithelium is the major compartment where TGF-βs/activins exert their biological effects via Smads... |
| Databáze: | OpenAIRE |
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