Daily rhythms of norepinephrine, β1-adrenoceptor mRNA, serotonin, arylalkylamineN-acetyltransferase mRNA, arylalkylamineN-acetyltransferase and hydroxyindol-O-methyltransferase activities, and melatonin in the pineal gland of viscacha
| Autor: | Lilian Eugenia Pelzer, Estela Muñoz, Morten M⊘ller, Claudia Patricia Calderón, Lucia B. Fuentes |
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| Rok vydání: | 2008 |
| Předmět: |
endocrine system
medicine.medical_specialty Physiology Period (gene) Adrenergic Viscacha Biology biology.organism_classification Melatonin Norepinephrine (medication) Pineal gland Endocrinology medicine.anatomical_structure Physiology (medical) Internal medicine Zeitgeber medicine Serotonin Ecology Evolution Behavior and Systematics medicine.drug |
| Zdroj: | Biological Rhythm Research. 39:93-107 |
| ISSN: | 1744-4179 0929-1016 |
| DOI: | 10.1080/09291010701324715 |
| Popis: | We described the daily rhythms of parameters involved in melatonin production in the pineal of viscacha. Norepinephrine showed the highest levels at night. A peak in β1-adrenoceptor mRNA was observed at the end of the light phase. Serotonin exhibited higher values during the light period. AA-NAT mRNA showed the highest expression at Zeitgeber time 0 (ZT0), reaching a minimum at night. AA-NAT activity and melatonin content exhibited a nocturnal peak at ZT16, a lower diurnal increase during the light period and minimal level at ZT8. HIOMT activity showed a peak at ZT16. The daily pattern in norepinephrine content was similar to that of AA-NAT activity and melatonin levels. Our data suggest that the melatonin synthesis in viscacha might be activated via adrenergic induction; the differences observed in the daily rhythms of AA-NAT activity and its mRNA suggest that post-transcriptional mechanisms may be involved, and other Zeitgeber and other mechanisms might also control melatonin production. |
| Databáze: | OpenAIRE |
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