Comparison of oral stanozolol with low dose heparin in prevention of deep venous thrombosis in high risk patients after elective major abdominal surgery
| Autor: | M.J. McMahon, H. M. Sue-Ling, J A Davies, J.L. Hosegood, D. Johnston |
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| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry medicine.medical_treatment Venography Hematology Heparin medicine.disease Fibrinogen Surgery law.invention Venous thrombosis Randomized controlled trial law Anesthesia Fibrinolysis medicine business Stanozolol Abdominal surgery medicine.drug |
| Zdroj: | Fibrinolysis. 2:37-41 |
| ISSN: | 0268-9499 |
| Popis: | A prospective randomised controlled trial of prophylaxis with oral stanozolol compared to standard low-dose subcutaneous heparin in prevention of deep venous thrombosis was carried out in 223 patients undergoing elective major abdominal surgery. A predictive index was used to divide the patients into high and low risk groups. Patients at high risk were randomised to receive either stanozolol, 10 mg orally daily for 2 weeks before operation and 1 week post-operatively, or subcutaneous heparin, 5000 units 2 h pre-operatively and 8 hourly thereafter for 1 week. Patients classified at low risk did not receive specific prophylaxis. Post-operative deep venous thrombosis was diagnosed by leg scanning following administration of iodine-125 labelled fibrinogen and the diagnosis confirmed by venography. Nine of 136 patients at low risk (6.6%) developed deep venous thrombosis. Nine of the 45 patients at high risk who received stanozolol (20%) developed DVT assessed by leg scan and 5(12/) determined by venography. In contrast only one of the 42 patients at high risk who received prophylaxis with heparin (2.4%) developed a positive leg scan and the diagnosis was not confirmed at venography. The differences between the numbers of patients who developed DVT in the two treatment groups were statistically significant both in terms of leg scanning (p=0.009) and of venography (p=0.03). Administration of oral stanozolol resulted in a significant increase in fibrinolytic activity pre-operatively, though it did not prevent the marked reduction in fibrinolysic activity which is known to occur on the first post-operative day. In spite of this presumably beneficial effect on fibrinolysis, stanozolol was significantly less effective than low-dose heparin in prevention of DVT. |
| Databáze: | OpenAIRE |
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