'Architextured' fluid management of biological liquids

Autor:	H J Palmer, R L Columbus
Rok vydání:	1987
Předmět:	Flow (mathematics) Rheology Capillary action Chemistry Solid surface Instrumentation Biochemistry (medical) Clinical Biochemistry Surface structure Nanotechnology Fluid management Mechanics Volumetric flow rate
Zdroj:	Clinical Chemistry. 33:1531-1537
ISSN:	1530-8561 0009-9147
DOI:	10.1093/clinchem/33.9.1531
Popis:	Novel "architextured" liquid-spreading and capillary flow systems are described as an adjunct to diagnostic procedures that range from the fully automated to techniques requiring no instrumentation. These systems were developed because of the observation that local features of macroscopic surfaces--roughness and chemical heterogeneity--influence both the spreading rate and equilibrium shape of liquid drops on solid surfaces. By use of organized patterns of surface structure complemented by surface chemical modification, this uncontrolled and undirected capillary flow is recast into flow behavior that is remarkably reproducible. Flow fronts are engineered to have prescribed shapes, and flow rates that are insensitive to the rheological properties of the biological liquids are obtained. To demonstrate the utility of fluid-management principles, we describe the implementation of architextured capillary configurations in microvolume liquid dispensers and potentiometric analytical systems.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cbf7f625bc932af0faa7dda6e1f74510 https://doi.org/10.1093/clinchem/33.9.1531 Zobrazit plný text záznamu