Practical Synthesis of A Macrocyclic HCV Protease Inhibitor: A High-Yielding Macrolactam Formation

Autor:	Andrew Nolting, Daniel Zewge, Jacob M. Janey, Zhiguo J. Song, David M. Tellers, Paul N. Devine, Steven F. Oliver, David M. Tschaen, Dietrich Steinhuebel, Peter G. Dormer
Rok vydání:	2014
Předmět:	chemistry.chemical_compound Stereochemistry Chemistry Organic Chemistry Hcv protease Sonogashira coupling Physical and Theoretical Chemistry Isoquinoline Key features
Zdroj:	Organic Process Research & Development. 18:423-430
ISSN:	1520-586X 1083-6160
Popis:	A practical synthesis of a macrocyclic HCV protease inhibitor, MK-1220, is described. The key features are a new synthesis of the trisubstituted isoquinoline, Sonogashira fragment coupling, and a high-yielding, 18-membered macrolactam formation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cbf334ca5638136824f43950b4968800 https://doi.org/10.1021/op400331j Zobrazit plný text záznamu