Antiplasmodial activity of the ethanol extract of Dacryodes edulis leaf in Plasmodium berghei infected mice

Autor:	Chikezie N. Okwesileze, Godwin C. Akuodor, Casimir C. Ofor, Daniel O. J. Aja, Gideon A. Ibiam, Cajetan E. Ilo
Rok vydání:	2022
Předmět:	General Medicine
Zdroj:	International Journal of Basic & Clinical Pharmacology. 11:296
ISSN:	2279-0780 2319-2003
DOI:	10.18203/2319-2003.ijbcp20221594
Popis:	Background: Malaria treatment in Africa is increasingly becoming difficult resulting from Plasmodium falciparum resistant to available antimalarial agents. Therefore, evaluating plants used in traditional medicines can lead to alternative treatment against malaria.Methods: This study evaluated the antiplasmodial activity of ethanol extract of Dacryodes edulis in chloroquine sensitive Plasmodium berghei NK65 strain in mice. The 4-day suppressive test, repository and curative effect against established rodent malaria infection models were assayed in this study. The oral acute toxicity test and phytochemical screening were also carried out on the ethanol leaf extract.Results: The ethanol leaf extract of Dacryodes edulis (D. edulis) at varying doses of 100 mg/kg, 200 mg/kg, 400 mg/kg significantly (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cbd254021c3111de39c3ae0f9952fc9c https://doi.org/10.18203/2319-2003.ijbcp20221594 Zobrazit plný text záznamu