Interstitial Pneumonia Related to Undifferentiated Connective Tissue Disease
| Autor: | Seung Bong Han, Se Jin Jang, Thomas V. Colby, Chang-Keun Lee, Ho Cheol Kim, Wonjun Ji, Mi Young Kim, Dong Soon Kim |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pathology medicine.medical_specialty business.industry Interstitial lung disease Undifferentiated connective tissue disease Lung biopsy respiratory system Critical Care and Intensive Care Medicine medicine.disease Connective tissue disease Gastroenterology respiratory tract diseases Pneumonia Idiopathic pulmonary fibrosis Usual interstitial pneumonia Internal medicine medicine Cardiology and Cardiovascular Medicine business Idiopathic interstitial pneumonia |
| Zdroj: | Chest. 147:165-172 |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.14-0272 |
| Popis: | BACKGROUND Undifferentiated connective tissue disease (UCTD) involves conditions characterized by both having symptoms of connective tissue disease (CTD) and autoantibodies but not fulfilling the criteria of a specific CTD. The frequency or prognosis of the usual interstitial pneumonia (UIP) pattern in UCTD is unknown, which may be confused with idiopathic pulmonary fibrosis (IPF). This study aimed to investigate the frequency of the UIP pattern in interstitial pneumonia related to UCTD and compare its prognosis with that of IPF and UCTD-nonspecific interstitial pneumonia (UCTD-NSIP). METHODS The medical records of 788 patients presumptively diagnosed with idiopathic interstitial pneumonia at Asan Medical Center from January 2005 to December 2012 were retrospectively reviewed. UCTD was diagnosed according to the criteria by Corte and colleagues, and the prognoses were compared between UCTD-UIP and UCTD-NSIP and between UCTD-UIP and IPF. RESULTS Among 105 patients with UCTD (13.3% of total subjects), 44 had a UIP pattern (by surgical lung biopsy: 24; by high-resolution CT scan: 20), 29 had a nonspecific interstitial pneumonia pattern (by surgical lung biopsy), and nine had an organizing pneumonia pattern (by biopsy). The overall survival of the UCTD-UIP group was shorter than that of the UCTD-NSIP group ( P = .021) but significantly better than that of the IPF group ( P = .042). CONCLUSIONS A UIP pattern, which seems to be frequent in UCTD, showed a poorer prognosis than that of UCTD-NSIP. However, the prognosis of UCTD-UIP was significantly better than that of IPF, highlighting the importance of searching for underlying UCTD in suspected IPF cases. |
| Databáze: | OpenAIRE |
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