Synthesis of Hybrid Compounds on the Basis of 4-[(1-Oxo-3,4-dihydro-2H-naphthalen-2-ylidene)methyl]benzoic acid

Autor:	O. V. Fedotova, A. L. Ivanova, I. V. Kanevskaya
Rok vydání:	2019
Předmět:	chemistry.chemical_classification Chalcone Double bond 010405 organic chemistry Dihydropyran Organic Chemistry Aromatization 01 natural sciences Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Pyridine Piperidine Triethylamine Benzoic acid
Zdroj:	Russian Journal of Organic Chemistry. 55:1231-1233
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428019080244
Popis:	The reactions of 4-[(1-oxo-3,4-dihydro-2H-naphmalen-2-ylidene)methyl]benzoic acid with 3-(1,3-dioxobutane-1-yl)-2H-chromen-2-one in the presence of nitrogenous bases (piperidine, triethylamine or pyridine) were used to synthesize for the first time hybrid systems containing the pharmacophoric fragments of the reagents. The reaction scheme involves formation of a condensed dihydropyran structure and its subsequent aromatization into a benzodihydrochromenilium salt under the action of HCl. The process may be accompanied by the competing addition of an azanucleophile by the double bond of the chalcone.
Databáze:	OpenAIRE
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