Phosphodiesterases in Normal and Dystrophic Human Muscle

Autor:	Carl M. Pearson, Nirmal C. Kar
Rok vydání:	1975
Předmět:	chemistry.chemical_classification Pathology medicine.medical_specialty Duchenne dystrophy Phosphodiesterase Dystrophy Anatomy Biology medicine.disease Polymyositis General Biochemistry Genetics and Molecular Biology Phosphodiesterase I Enzyme Human muscle chemistry medicine
Zdroj:	Experimental Biology and Medicine. 148:1005-1008
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-148-38677
Popis:	SummaryThe levels and some properties of phosphodiesterase I and phosphodi-esterase II were determined in biopsied muscles from normal persons and the results were extended to diseased muscles. The activities of both enzymes were generally normal or minimally elevated in mildly affected muscles from patients with Duchenne dystrophy, other forms of dystrophies and related neuromuscular diseases. However, in severely abnormal muscles, with advanced dystrophy or advanced polymyositis, the levels of these enzymes were greatly elevated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cbbda8e11c937fcd244db251f19071f2 https://doi.org/10.3181/00379727-148-38677 Zobrazit plný text záznamu