Multiple myeloma in elderly patients: presenting features and outcome
| Autor: | Lotfi Benboubker, Virginie Lucas, J. Dugay, Philippe Goupille, Jean-Bernard Gauvain, Philippe Rodon, Claude Linassier, Michel Maigre, François Luthier, Philippe Colombat |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
education.field_of_study
Creatinine medicine.medical_specialty Chemotherapy Performance status business.industry medicine.medical_treatment Population Hematology General Medicine medicine.disease Comorbidity Surgery Clinical trial chemistry.chemical_compound chemistry Quality of life Internal medicine medicine education business Multiple myeloma |
| Zdroj: | European Journal of Haematology. 66:11-17 |
| ISSN: | 0902-4441 |
| DOI: | 10.1034/j.1600-0609.2001.00301.x |
| Popis: | Few studies have been performed regarding multiple myeloma (MM) in elderly patients. We report a retrospective series of 130 unselected patients with MM aged 75 yr or more at diagnosis. Presenting features were identical to those reported in younger patients, except for a higher rate of infection. Heavy comorbidity was characteristic of unselected geriatric patients. Ninety-four patients received conventional chemotherapy. The response rate was 62%. Treatment toxicity was mild. Median survival was 22 months. Durie–Salmon (DS) clinical stages II and III MM were severe and often led to death, while significantly more patients with DS stage I MM died from unrelated causes (p 4 mg/l, C-reactive protein level >6 mg/l, platelet count |
| Databáze: | OpenAIRE |
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