Asymmetric Synthesis of Letermovir Using a Novel Phase-Transfer-Catalyzed Aza-Michael Reaction
| Autor: | Michael Shevlin, Melodie Christensen, Bangping Xiang, Michael R. Luzung, David M. Tschaen, Teresa Andreani, Stephen M. Dalby, Guy R. Humphrey, Zhiguo Jake Song, Kevin M. Belyk |
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| Rok vydání: | 2016 |
| Předmět: |
010405 organic chemistry
Chemistry Stereochemistry Organic Chemistry Enantioselective synthesis 010402 general chemistry 01 natural sciences 0104 chemical sciences Stereocenter Catalysis Letermovir chemistry.chemical_compound Phase (matter) Yield (chemistry) Michael reaction medicine Physical and Theoretical Chemistry Cinchonidine medicine.drug |
| Zdroj: | Organic Process Research & Development. 20:1097-1103 |
| ISSN: | 1520-586X 1083-6160 |
| DOI: | 10.1021/acs.oprd.6b00076 |
| Popis: | The development of a concise asymmetric synthesis of the antiviral development candidate letermovir is reported, proceeding in >60% yield over a total of seven steps from commercially available materials. Key to the effectiveness of this process is a novel cinchonidine-based PTC-catalyzed aza-Michael reaction to configure the single stereocenter. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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