The temporal profile of retinal cell genesis in the marmoset monkey
| Autor: | Daniel E. Possin, J. Huang, William C. Kwan, Anita E. Hendrickson, James A. Bourne |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Retina genetic structures biology General Neuroscience Immunocytochemistry Marmoset Retinal biology.organism_classification Callithrix 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure chemistry biology.animal medicine Primate sense organs Neuron Neuroscience Muller glia 030217 neurology & neurosurgery |
| Zdroj: | Journal of Comparative Neurology. 524:1193-1207 |
| ISSN: | 0021-9967 |
| DOI: | 10.1002/cne.23897 |
| Popis: | The New World marmoset monkey (Callithrix jacchus) has a relatively short gestational period compared with other primates but possesses a retina at a similar stage of maturation by birth. Previous studies have highlighted that the complex fovea of the marmoset undergoes a more rapid postnatal development in comparison with the Macaca monkey, reaching a mature stage earlier than these species. In this current study, we examined the prenatal proliferation profile of cells in the entire retina employing the thymidine analogs and also determined their phenotype by double-label immunocytochemistry using type-specific markers. Akin to other primate species, we demonstrate a centroperipheral gradient in the emergence of both neurons and Muller glia with cones, ganglion cells, and horizontal cells generated first in the fovea at fetal day (Fd)70-74 and with the last generated at the retinal edge at Fd115. Rods, bipolar cells, amacrine cells, displaced amacrine cells, and Muller glia were generated between Fd76 and Fd135 along the same gradient. Similar to foveal development, marmoset neuronal generation was rapid, only taking 51% of gestation whereas in Macaca this takes 81%. |
| Databáze: | OpenAIRE |
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