Enrichment of Bio-Active Phthalides in Celery Seed Oil

Autor:	null Halagur B. Sowbhagya, null Pullabhatla Srinivas
Rok vydání:	2013
Předmět:	Celery Seed Oil Horticulture Nutrition and Dietetics Health (social science) Chemistry Medicine (miscellaneous) General Pharmacology Toxicology and Pharmaceutics
Zdroj:	Journal of Pharmacy and Nutrition Sciences. 3:250-257
ISSN:	1927-5951 2223-3806
DOI:	10.6000/1927-5951.2013.03.04.6
Popis:	Objective: To develop an efficient process to obtain a phthalide-enriched nutraceutical fraction from celery seed oil.Methods: Three approaches viz., fractional distillation, column chromatography and solvent-solvent partition, have been used.Results: Fractional distillation of celery seed oil (13.7g) afforded i) a limonene-rich fraction (7.6g, 97% purity), ii) a fraction containing β-selinene (2.8 g, 90 % purity) and iii) one containing phthalides (2.9 g, 90 % purity). Solvent-solvent partition of celery seed oil gave limonene (87%) and a fraction containing phthalides (49%), which on further fractionation afforded a phthalide-enriched fraction (90%). By conventional silica gel column chromatography, a product rich in phthalides (53-74%) could be obtained.Conclusion: Fractional distillation is shown to be a viable method to process celery seed oil into a phthalide-enriched product with high nutraceutical potential.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cbac9b4b17f30a90f1cb081b959d8841 https://doi.org/10.6000/1927-5951.2013.03.04.6 Zobrazit plný text záznamu