ChemInform Abstract: Chemical and Cytotoxic Constituents from the Stem of Machilus zuihoensis

Autor: Bolleddula Jayaprakasam, Hiroko Seki, Ming‐Jen Cheng, Ian-Lih Tsai, Ih-Sheng Chen, Tsutomu Ishikawa, Jeh-Jeng Wang
Rok vydání: 2010
Předmět:
Zdroj: ChemInform. 33
ISSN: 1522-2667
0931-7597
DOI: 10.1002/chin.200248207
Popis: Five new compounds, including a novel lactone, machilactone (=rel-(2R,3aR,6E,6aS)-2-heptadecyl-3a-methyl-6-octadecylidene-6,6a-dihydrofuro[2,3-d][1,3]dioxol-5(3aH)-one; 1), a new sesquiterpene, 3,4-dihydroxy-β-bisabolol (=rel-(1R,2S,4R)-1-[(1R)-1,5-dimethylhex-4-enyl]-1-methylcyclohexane-1,2,4-triol; 2), a new secobutyrolactone, methyl (2E)-2-(1-hydroxy-2-oxopropyl)eicos-2-enoate (3), two new butyrolactones, machicolide A (4) and machicolide B (5) (=3E,4R,5R)- and (3Z,4R,5R)-4,5-dihydro-4-hydroxy-5-methoxy-5-methyl-3-octadecylidenefuran-2(3H)-one, resp.) as a mixture, together with known caryophyllene oxide (=4,12,12-trimethyl-9-methylene-5-oxatricyclo[8.2.0.04,6]dodecane), hexacosane, tetracosanoic acid, isomahubanolide-23 (=(3E,4R)-4,5-dihydro-4-hydroxy-5-methylidene-3-octadecylidenefuran-2(3H)-one), and β-bisabolol (=(1S)-1-[(1S)-1,5-dimethylhex-4-enyl]-4-methylcyclohex-3-en-1-ol) were isolated from the stem wood of Machilus zuihoensis. The structures of these compounds were established by spectroscopic studies. The eicos-2-enoate (3) and β-bisabolol exhibited marginal cytotoxicity against NUGC and HONE-1 cancer cell lines in vitro.
Databáze: OpenAIRE
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