| Popis: |
A central role for Ca2+ in stimulus-secretion coupling has been demonstrated in many secretory systems. Generally, an increase in intracellular Ca2+ stimulates secretion, but studies by Peart and colleagues suggested that the opposite may be true for renin. It was known that in smooth muscle cells, from which juxtaglomerular cells are thought to be derived (1), an increase in intracellular Ca2+ produced contraction (2). The possibility that changes in Ca2+ flux in JG cells may alter renin secretion was investigated in a series of studies using the isolated perfused kidney. |
