Liposomes as Carriers of Anticancer Medicines

Autor:	A. Hartabus, Wiesław W. Sułkowski, A. Kos, Z. Zawada, M. Maciążek-Jurczyk, M. Żądło, J. Równicka-Zubik, A. Szkudlarek-Haśnik, Anna Sułkowska, Izabela Czopek
Rok vydání:	2012
Předmět:	Liposome Phase transition temperature Chromatography Chemistry Vesicle technology industry and agriculture lipids (amino acids peptides and proteins) General Materials Science General Chemistry Condensed Matter Physics
Zdroj:	Molecular Crystals and Liquid Crystals. 555:218-224
ISSN:	1563-5287 1542-1406
DOI:	10.1080/15421406.2012.635542
Popis:	The aim of the work was the successful encapsulation of etoposide (ETO) and vinorelbine (VIN). Liposomes made from dipalmitylphosphatidylcholine (DPPC), liposomes containing both drugs (DPPC/ETO/VIN) and control liposomes DPPC/ETO and DPPC/VIN were prepared by the mREV method at 328 K. Liposome entrapped drugs were separated from free drugs by ultracentrifugation. The degree of encapsulation of drugs into liposome vesicles DPPC/ETO, DPPC/VIN and DPPC/ETO/VIN was estimated using UV spectrofluorescence after ultracentrifugation. The phase transition temperature was determined for all types of liposomes. The encapsulation efficiency, which is a measure of the percentage of the total compound entrapped within the liposome, is also determined.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cb9586b8cf4bb03e9ec7295740e77bec https://doi.org/10.1080/15421406.2012.635542 Zobrazit plný text záznamu