Left ventricular strain and left atrial strain are impaired during hemodialysis in children

Autor: Jessica Geer, Nancy A. Ayres, Ricardo H. Pignatelli, Carolyn A. Altman, Asela Liu, Robert W. Loar, J. Kevin Wilkes, Poyyapakkam Srivaths, Alexandra Idrovo, Sarah J. Swartz, Tam Doan, Ayse Akcan-Arikan
Rok vydání: 2021
Předmět:
Zdroj: The International Journal of Cardiovascular Imaging. 37:3489-3497
ISSN: 1573-0743
1569-5794
DOI: 10.1007/s10554-021-02350-9
Popis: We aimed to investigate intradialytic changes in ventricular and atrial function using speckle tracking echocardiography (STE) in pediatric hemodialysis (HD). Children with HD vintage > 3 months were enrolled, and echocardiography was performed prior to, during, and after HD. STE was analyzed using GE EchoPAC. Left ventricular (LV) global longitudinal strain (GLS), strain rate (Sr), and mechanical dispersion index (MDI) were calculated as the average from 3 apical views; diastolic strain (Ds) and Sr from 4-chamber tracing; left atrial strain (LAS) and Sr from the 4- and 2-chamber views. A total of 15 patients were enrolled at a median age of 12 years (IQR 8, 16) and median HD vintage of 13 months (IQR 9, 25). GLS worsened during HD (− 15.8 ± 2.2% vs − 19.9 ± 1.9%, p 0.1). In conclusions, intradialytic LV strain and LAS changes consistent with subclinical systolic and diastolic dysfunction were observed during HD in children. Changes in Ds, DSr, LAS, and LASr were not associated with BP change or BV removal and may be related to the disease progression. Longitudinal study using these novel indices may unfold the effect of these subclinical changes on long-term cardiovascular health in children requiring chronic HD.
Databáze: OpenAIRE
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