Improving the Detection of Cholangiocarcinoma: In vitro MRI-Based Study Using Local Coils and T2 Mapping
| Autor: | Attapol Titapun, Simon D. Taylor-Robinson, Nittaya Chamadol, Evdokia M. Kardoulaki, Narong Khuntikeo, Wuttisak Boonphongsathien, Shuo Zhang, Christopher A. Wadsworth, Ian R. Young, Richard R. A. Syms, Prakasit Sa-Ngiamwibool |
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| Rok vydání: | 2020 |
| Předmět: |
Relaxometry
Hepatology medicine.diagnostic_test Endoscope Orientation (computer vision) business.industry Magnetic resonance imaging Torso 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Electromagnetic coil 030220 oncology & carcinogenesis Medical imaging medicine 030211 gastroenterology & hepatology Sensitivity (control systems) business Biomedical engineering |
| Zdroj: | Hepatic Medicine: Evidence and Research. 12:29-39 |
| ISSN: | 1179-1535 |
| DOI: | 10.2147/hmer.s232392 |
| Popis: | Aim Cholangiocarcinoma is endemic in southeast Asia, generally developing from liver fluke infestation. However, diagnostic imaging of early-stage disease is challenging. The aim of this work is to investigate relaxometry (specifically, T2 mapping) as a method of exploiting the higher signal-to-noise ratio (SNR) of internal coils for improved reception of magnetic resonance signals, despite their non-uniform sensitivity. Methods Ex vivo T2 mapping was carried out at 3T on fixed resection specimens from Thai cholangiocarcinoma patients using an mGRASE sequence and an endoscope coil based on a thin-film magneto-inductive waveguide and designed ultimately for internal use. Results Disease-induced changes including granulomatous inflammation, intraepithelial neoplasia and intraductal tumours were correlated with histopathology, and relaxation data were compared with mono- and bi-exponential models of T2 relaxation. An approximately 10-fold local advantage in SNR compared to a 16-element torso coil was demonstrated using the endoscope coil, and improved tissue differentiation was obtained without contrast agents. Conclusion The performance advantage above follows directly from the inverse relation between the component of the standard deviation of T2 due to thermal noise and the SNR, and offers an effective method of exploiting the SNR advantage of internal coils. No correction is required, avoiding the need for tracking, relaxing constraints on coil and slice orientation and providing rapid visualization. |
| Databáze: | OpenAIRE |
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