Inhalation studies of Mt. St. Helens volcanic ash in animals
| Autor: | Gary E. Hatch, Ping Chuan Hu, James A. Raub, Robert R. Mercer, Margaret A. Grady |
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| Rok vydání: | 1985 |
| Předmět: |
inorganic chemicals
Pathology medicine.medical_specialty Lung Inhalation medicine.medical_treatment technology industry and agriculture respiratory system medicine.disease complex mixtures Biochemistry respiratory tract diseases Pulmonary function testing Hydroxyproline chemistry.chemical_compound medicine.anatomical_structure chemistry Fibrosis medicine Respiratory system Saline General Environmental Science Volcanic ash |
| Zdroj: | Environmental Research. 37:72-83 |
| ISSN: | 0013-9351 |
| DOI: | 10.1016/0013-9351(85)90050-7 |
| Popis: | Rats were exposed by inhalation to 9.4 mg/m3 size-fractionated volcanic ash for 5 days (2 hr/day) and examined for changes in pulmonary function and histology for periods of up to 1 year. Fine-mode volcanic ash, SO2, and a combination of ash and SO2 produced no observable effects in normal rats and rats with elastase-induced emphysema. However, there was a mild irritant response to SO2 which was not influenced by the volcanic ash. Rats injected intratracheally with fine-mode volcanic ash or saline showed no evidence of pulmonary alterations after 6 months. Those injected with coarse-mode volcanic ash showed minor pulmonary functional changes, histologically detectable alveolitis, and small increases in lung weight. In contrast, quartz-injected rats showed large alterations in pulmonary function, lung weight, hydroxyproline levels, and large areas of lung consolidation and fibrosis. |
| Databáze: | OpenAIRE |
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