L-683,877: Pharmacological profile of a novel 5-HT3 receptor antagonist

Autor:	Kneen Clare O, Michael J. Gilbert, David F. Tattersall, A.T. McKnight, Mark Duchnowski, Colin T. Dourish, Nigel R. Newberry, Margaret S. Beer, Nikki Mudunkotuwa, Michael Rigby, Christopher John Swain, Janet J. Maguire
Rok vydání:	1992
Předmět:	Chronotropic medicine.medical_specialty Superior cervical ganglion medicine.drug_class business.industry Receptor antagonist Vagus nerve Endocrinology 5-HT3 Receptor Antagonist Bezold–Jarisch reflex In vivo Internal medicine 5-HT3 antagonist Drug Discovery medicine business medicine.drug
Zdroj:	Drug Development Research. 25:17-28
ISSN:	1098-2299 0272-4391
DOI:	10.1002/ddr.430250103
Popis:	The 5-HT3 receptor antagonist properties of the novel compound L-683,877 (−) (2′-(1-methyl-1H-indol-3-yl)-)spiro(1-azabicyclo[2.2.2]octane-3,5′(4′H)-oxazole) have been characterised in vitro and in vivo. In radioligand binding studies, L-683,877 displaced [3H]quaternized ICS 205–930 binding to membranes of rat cortex with a pKi of 8.71. L-683,877 was essentially inactive (pKi
Databáze:	OpenAIRE
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