Secretion by Micromycetes of Proteases with Activity Similar to the Activity of the Hemostatic System Proteins
| Autor: | Anna A. Lukianova, A. V. Kurakov, V. G. Kreyer, A. A. Osmolovskiy, P. A. Vigand, E. I. Kornienko |
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| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Urokinase 0303 health sciences Proteases biology Chemistry 030302 biochemistry & molecular biology Human pathogen Peptide biology.organism_classification Tissue plasminogen activator General Biochemistry Genetics and Molecular Biology Arthrobotrys Microbiology 03 medical and health sciences Purpureocillium lilacinum medicine Secretion General Agricultural and Biological Sciences 030304 developmental biology General Environmental Science medicine.drug |
| Zdroj: | Moscow University Biological Sciences Bulletin. 75:31-35 |
| ISSN: | 1934-791X 0096-3925 |
| DOI: | 10.3103/s009639252001006x |
| Popis: | Proteolytic activity of 8 strains of micromycetes (belonging to different ecological and trophic groups: phyto-, nemato-, myco-, and entomopathogens as well as human pathogens) toward the hemostatic system proteins has been assayed by using the chromogenic peptide substrates. The investigated micromycetes are shown to secrete proteases with a broad substrate specificity. However, there are producers among them exhibiting a pronounced plasmin-like and urokinase activity (Arthrobotrys longa 1, Sarocladium strictum 203) as well as a tPA (tissue plasminogen activator)-like activity (Purpureocillium lilacinum k1). It is found that the most active producer of proteases with fibrinolytic and plasminogen activator activity is S. strictum 203. Plasminogen activator activity of proteinases produced by S. strictum 203 is approximately 50% of the fibrinolytic one, which makes this strain a promising producer of fibrinolytic enzymes. |
| Databáze: | OpenAIRE |
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