Effects of a crude preparation of colostrokinin compared with thoseof bradykinin on isolated rat duodenal segments

Autor:	R. Faustini, C. Beretta, P. Ormas, G. Gallina
Rok vydání:	1972
Předmět:	Pharmacology chemistry.chemical_classification Chemistry Bradykinin Peptide chemistry.chemical_compound Biochemistry Catecholamine medicine Colostrum Antispasmodic Colostrokinin Incubation medicine.drug
Zdroj:	Pharmacological Research Communications. 4:87-95
ISSN:	0031-6989
DOI:	10.1016/s0031-6989(72)80002-x
Popis:	Summary A crude preparation of colostrokinin (CCOLK) obtained from pretreated bovine colostrum showed relaxing effects on isolated rat duodenal segments. These effects proved to be independent from catecholamine release and unrelated to true antispasmodic properties of the extract. Through various kinds of assays performed, CCOLK revealed some features resembling those of bradykinin and others which make the two substances clearly different. By changing the pH of the incubation media of the isolated preparations, CCOLK showed an interesting reversal of activity. The results obtained with a crude extract however should be further confirmed with pure colostrokinin or, better still, with a synthetic preparation of this peptide.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cb811a06f5df2c12b68437c7333bef0c https://doi.org/10.1016/s0031-6989(72)80002-x Zobrazit plný text záznamu