Organic solvent enhanced a-helical formation of a nonadecapeptide derived from Trichosanthin (TCS 182-200)

Autor:	Hu Hongyu, Lu Zixian, Du Yucang
Rok vydání:	2010
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Circular dichroism Chemistry Organic solvent Organic chemistry Alcohol Peptide General Chemistry Trichosanthin Dielectric
Zdroj:	Chinese Journal of Chemistry. 16:153-161
ISSN:	1001-604X
DOI:	10.1002/cjoc.19980160208
Popis:	A model peptide, TDK, was studied by circular dichroism to elucidate the effect of organic solvent on α-helical formation. The a-helicities enhanced by various alcohol solvents, especially fluorine-substituted alcohols were systematically compared. The relations between a-helical formation of a peptide and external environment were also discussed in detail. These environmental elements mainly include hydrophobicity, dielectric constant and acidity of the solvents.
Databáze:	OpenAIRE
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