SHORT COMMUNICATION: Image Analysis of Nucleomegalic Cells in Chagas' Disease Placentitis

Autor:	R. Drut, M.O.G. Araujo
Rok vydání:	2000
Předmět:	Chagas disease biology Obstetrics and Gynecology Kinetoplastida Cell cycle medicine.disease biology.organism_classification Virology Pathogenesis Reproductive Medicine Stroma medicine Protozoa Ploidy Trypanosomiasis Developmental Biology
Zdroj:	Placenta. 21:280-282
ISSN:	0143-4004
DOI:	10.1053/plac.1999.0468
Popis:	Villous stroma nucleomegalic cells harbouring intracytoplasmic parasites are an unusual finding which appears to be restricted to Chagas' disease placentitis. Ploidy analysis of these cells in two cases (twelve nuclei in Case 1 and 26 in Case 2) showed these nuclei to contain quantitatively abnormal DNA. Only a few were diploid, the rest proving to be tetraploid, hypertetraploid and even aneuploid. Little is known about the pathogenesis of these macronuclei. However, since these cells contain large numbers of parasites it is possible that a parasite-induced derangement of the cell cycle at G2 phase may be operative.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cb756aa1badce849f5069cc14bb20b3a https://doi.org/10.1053/plac.1999.0468 Zobrazit plný text záznamu Full Text from ScienceDirect