| Autor: | Michio Imawari, Hiromitsu Kumada, Namiki Izumi, Mikio Zeniya, Naoaki Hashimoto, Hideharu Harada, Gotaro Toda |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
biology Physiology business.industry Hepatitis C virus Hepacivirus Gastroenterology Hepatitis C Hepatology medicine.disease medicine.disease_cause biology.organism_classification Group A Group B Flaviviridae Interferon Internal medicine Immunology medicine business medicine.drug |
| Zdroj: | Digestive Diseases and Sciences. 46:516-523 |
| ISSN: | 0163-2116 |
| Popis: | Virological response to interferon (IFN) is poor in patients with plasma levels of HCV RNA higher than 1 Meq/ml and genotype 1b hepatitis C viral infection. In 60 patients, a randomized control study was conducted to compare 3 MU of IFN-β twice daily for four weeks (group A) and 6 MU once a day for four weeks (group B) followed by a four-week administration of 6 MU once a day. The plasma levels of HCV RNA, determined by an amplicore-monitor method, for patients in group A were significantly lower than those for group B at the fourth and eighth day of IFN administration, and complete virological responses were noted in two patients from group A but none in group B. It is concluded that twice daily administration of 3 MU IFN-β is more effective than once a day 6 MU in the early phase of IFN therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink