The Properdin System and Immunity
| Autor: | Carl F. Hinz, Ralph J. Wedgwood, Earl W. Todd, Louis Pillemer |
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| Rok vydání: | 1960 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 85:547-558 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.85.6.547 |
| Popis: | Summary Partially purified human properdin was injected intravenously into rabbits. In one series of animals there was a marked rise in serum properdin level. In a subsequent series no consistent change was observed. Antibodies to several constituents of human serum appeared following the initial course of injections. Antibodies to properdin did not appear after the initial injections, but did develop after restimulation. The antibody to properdin interfered with the properties of human serum requiring the properdin system. These included inactivation of C′3 by Zymosan, hemolysis of PNH erythrocytes, lysis of certain bacteria, and inhibition of some viruses. The antibody to properdin reacted with properdin as a single line by agar diffusion which was distinct from the other antibodies to human serum which appeared. Properdin could be distinguished from antibodies to 7S and 19S γ-globulins. The evidence supports the hypothesis that properdin is a single substance with multiple biologic properties. |
| Databáze: | OpenAIRE |
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