Mitochondrial Dysfunction in Diabetic Cardiomyopathy

Autor:	Jae Taek Kim, Ji Hyun Ahn
Rok vydání:	2008
Předmět:	medicine.medical_specialty business.industry Energy metabolism Type 2 diabetes Mitochondrion medicine.disease Coronary artery disease Pathogenesis Diabetes mellitus Internal medicine Diabetic cardiomyopathy medicine Cardiology Metabolic syndrome business
Zdroj:	Korean Diabetes Journal. 32:467
ISSN:	1976-9180
DOI:	10.4093/kdj.2008.32.6.467
Popis:	Metabolic syndrome and diabetes are associated with increased r isk of cardiac dysfunction independently of underlying coronary artery disease. The underlying pathogenesis is partially understood but accumulating evidence suggests that alterations of cardiac energy metabolism might contribute to the development of contractile dysfunction. Recent findings suggest that myocardial mitochondrial dysfunction may play an important role in the pathogenesis of cardiac contractile dysfu nction in type 2 diabetes. This review is focused on evaluating mechanisms for the mitochondrial abnormalities that may be involved in the development and progression of cardiac dysfunction in diabetes. (KOREAN DIABETES J 32:467-473, 2008)
Databáze:	OpenAIRE
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