| Autor: |
James Chang, Graham Rushton, J Duerig, Karen P. Schofield |
| Rok vydání: |
1999 |
| Předmět: |
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| Zdroj: |
British Journal of Haematology. 106:524-527 |
| ISSN: |
0007-1048 |
| DOI: |
10.1046/j.1365-2141.1999.01583.x |
| Popis: |
Interactions between integrins on haemopoietic progenitor cells and their stromal ligands have an important role in the control of haemopoiesis. Growth factors can modulate these interactions (so-called ‘inside-out’ signalling) resulting in changes in ligand binding activity. We have studied α4β1 integrin-mediated adhesion to the H120 fragment of fibronectin (which contains the strongest α4β1 binding site) in CD34+ cells from patients with chronic myeloid leukaemia (CML) and have determined the effect of IL-3 on the level of adhesion. Compared to normal CD34+ cells isolated from cord blood and peripheral blood progenitor harvests (mean of 61.4 ± 14.9% of cells attached) the CML CD34+ cells showed reduced levels of adhesion (mean of 41.9 ± 14.7%, P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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