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Objectives: This retrospective study aims to estimate the prevalence of neuroendocrine disturbances as early as six months after traumatic brain injury (TBI) in patients hospitalized in intensive functional rehabilitation (IFR).Methods: Retrospective study of all patients aged 17 years or older admitted to an IFR between 2014-2016 with a diagnosis of mild-complex to severe TBI. Charts were reviewed (N=300) and those with neuroendocrine lab results were retained (N=56). Pituitary-dependent hormone dosages were collected. Results: An estimated prevalence between 4.67 and 30.43% with at least one hormonal anomaly was noted. Compared to the literature, lower disturbances for all pituitary axes except central adrenal insufficiency were observed. The most significant prevalence in our cohort is of the adrenal axis estimated at 4 and 26.09%, while for thyroid, gonadal and growth hormone axes, a suspicion of disturbance was detected in a single patient per axis for an estimated prevalence of 0.33 to 2.17% each.Conclusion: Results did not show a very significant prevalence in chronic patients with TBI who were hospitalized in IFR. We believe that systematic testing is not necessary and propose workups only if symptomatic and after a comprehensive clinical history. Hypopituitarism is complex, and endocrinology consultation is recommended. |
