Synthesis of Mono N-Substituted Guanylthioureas

Autor:	Goldsmith Miriam E, Lawrence A. Reiter, Katherine E. Brighty, Rhonda A. Bryant
Rok vydání:	1996
Předmět:	chemistry.chemical_compound chemistry Hydrogen sulfide Dithiobiuret Organic Chemistry Single step Combinatorial chemistry Derivative (chemistry)
Zdroj:	Synthetic Communications. 26:1423-1429
ISSN:	1532-2432 0039-7911
DOI:	10.1080/00397919608003504
Popis:	A convenient method for the synthesis of mono N-substituted guanylthioureas in reasonable yields from readily available starting materials has been developed. In contrast to the previously published method, the use of highly noxious hydrogen sulfide is avoided. The method allows the rapid preparation of guanylthioureas since the synthesis of each requires only a single step from a common intermediate, the S-methylated derivative of dithiobiuret.
Databáze:	OpenAIRE
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