Minimum alveolar concentrations of sevoflurane for maintaining bispectral index below 50 in children
| Autor: | Takeru Shimizu, Shinichi Inomata, Shouhei Tsuruta, Taro Mizutani, Tsuyoshi Satsumae, Makoto Tanaka, Shinji Takahashi |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Minimum alveolar concentration
Inhalation business.industry medicine.medical_treatment Tracheal intubation Sevoflurane Confidence interval Anesthesiology and Pain Medicine Bispectral index Anesthesia Pediatrics Perinatology and Child Health Medicine Consciousness monitors business medicine.drug American society of anesthesiologists |
| Zdroj: | Pediatric Anesthesia. 21:1124-1127 |
| ISSN: | 1155-5645 |
| DOI: | 10.1111/j.1460-9592.2011.03602.x |
| Popis: | Summary Objective: To determine minimum alveolar concentration (MAC) of sevoflurane for maintaining bispectral index (BIS) below 50 (MACBIS50) in children. Background: MACBIS50 of sevoflurane in adults was reported to be 0.97%, which has not been elucidated in children. Methods/Materials: Twenty children, American Society of Anesthesiologists physical status I or II, aged 1–8, were induced and anesthetized with sevoflurane in oxygen. After tracheal intubation, we started maintenance of anesthesia with endtidal sevoflurane concentrations of 2.6%. The endtidal sevoflurane concentration at which BIS was measured was predetermined by the up-down method (with 0.2% as a step size). After 10 min at predetermined endtidal sevoflurane concentrations, BIS was measured for 1 min. MACBIS50 was determined using Dixon’s up-down method and probit test. Result: MACBIS50 of sevoflurane was 2.83% (95% confidence intervals: 2.70–3.14) in children. Conclusions: MACBIS50 of sevoflurane in children was calculated to be three times as high as in adults. This indicates that high endtidal sevoflurane concentration is required to suppress electroencephalogram activity in children. |
| Databáze: | OpenAIRE |
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