Reaction kinetic monitoring by high performance liquid chromatography coupled to mass spectrometry: Oxidation processes of selected isothiazoles

Autor:	Monika Möder, B. Schulze, Sven Baumann, Rainer Herzschuh
Rok vydání:	2003
Předmět:	Acetic acid chemistry.chemical_compound Chromatography chemistry Liquid chromatography–mass spectrometry Organic Chemistry Clinical Biochemistry Kinetic energy Mass spectrometry Biochemistry High-performance liquid chromatography Analytical Chemistry
Zdroj:	Chromatographia. 57:S147-S152
ISSN:	1612-1112 0009-5893
Popis:	A HPLC-MS(MS) method is presented here for reaction monitoring of the oxidation of isothiazolium salts with H2O2/acetic acid. The comprehension of this mechanism was the aim of this work using several N-functionalized substances for the investigation. The strong acidic reaction mixture was separated on a RP-18 reversed-phased column without any sample pretreatment and occurring intermediates were identified by API-MS(MS) techniques. Thus, it was possible to gain detailed information about the course of oxidation and to develop an oxidation scheme of existing reaction pathways.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cb46848f39d675e4ebae06bf679fbfe3 https://doi.org/10.1007/bf02492097 Zobrazit plný text záznamu Full text from SpringerLink