Three-Component One-Pot Synthesis of New 2,5,6,7- and 2,5,8,10-Substituted Pyrimido[4,5-b]quinoline-4,6-diones and -2,4,6-Triones

Autor:	G. A. Panosyan, T. R. Hovsepyan, S. G. Israelyan, G. S. Karakhanyan
Rok vydání:	2018
Předmět:	010405 organic chemistry Quinoline One-pot synthesis General Chemistry 010402 general chemistry 01 natural sciences Chloride Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Dimedone medicine medicine.drug
Zdroj:	Russian Journal of General Chemistry. 88:1114-1119
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363218060117
Popis:	A series of new pyrimido[4,5-b]quinoline derivatives was synthesized by three-component cyclocondensation of 2-R1-6-aminopyrimidine-4-ones, 5,5-dimethylcyclohexane-1,3-dione (dimedone), and aromatic or heterocyclic aldehydes in a water medium in the presence of triethylbenzylammonium chloride. The replacement of the primary amino group in the position 6 of the key 6-aminopyrimidin-4-one with the secondary amino group led to the formation of 10-substituted analogs of pyrimido[4,5-b]quinolines which are of interest for biological screening.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cb3b76f3cb5e511ec1edc9c8e9866a3d https://doi.org/10.1134/s1070363218060117 Zobrazit plný text záznamu Plný text ve formátu PDF