Global Trends in Resistance to Antituberculosis Drugs

Autor:	Marcos A. Espinal, Adalbert Laszlo, S. J. Kim, Hans L. Rieder, Lone Simonsen, Fadila Boulahbal, Sven Hoffner, Mario C. Raviglione, Rosamund Williams, Ana Reniero, Nancy J. Binkin, Christopher Dye
Rok vydání:	2001
Předmět:	medicine.medical_specialty Tuberculosis business.industry Background data Resistance (psychoanalysis) General Medicine Drug resistance medicine.disease World health Surgery Anti tuberculosis Lung disease Environmental health Global health Medicine business
Zdroj:	New England Journal of Medicine. 344:1294-1303
ISSN:	1533-4406 0028-4793
DOI:	10.1056/nejm200104263441706
Popis:	Background Data on global trends in resistance to antituberculosis drugs are lacking. Methods We expanded the survey conducted by the World Health Organization and the International Union against Tuberculosis and Lung Disease to assess trends in resistance to antituberculosis drugs in countries on six continents. We obtained data using standard protocols from ongoing surveillance or from surveys of representative samples of all patients with tuberculosis. The standard sampling techniques distinguished between new and previously treated patients, and laboratory performance was checked by means of an international program of quality assurance. Results Between 1996 and 1999, patients in 58 geographic sites were surveyed; 28 sites provided data for at least two years. For patients with newly diagnosed tuberculosis, the frequency of resistance to at least one antituberculosis drug ranged from 1.7 percent in Uruguay to 36.9 percent in Estonia (median, 10.7 percent). The prevalence increased in Estonia, from 28....
Databáze:	OpenAIRE
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