B-type natriuretic peptide is a prognostic marker after myocardial infarction: Two-years survival study of 86 patients
| Autor: | Naoufel Nabli, N. Benrejeb, W. Amri, Lamia Rebhi, Ali Bouslama, J. Zemni, Asma Omezzine, A. Abdelaziz, E. Boughzala, I. Belhadjmbarek, J. Rejeb, M.A. Bouchhima |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.drug_class Biochemistry (medical) Clinical Biochemistry Infarction Odds ratio medicine.disease Brain natriuretic peptide Confidence interval Surgery Immunopathology Internal medicine cardiovascular system Natriuretic peptide Cardiology Medicine cardiovascular diseases Fresh frozen plasma Myocardial infarction business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Immuno-analyse & Biologie Spécialisée. 25:266-271 |
| ISSN: | 0923-2532 |
| DOI: | 10.1016/j.immbio.2010.09.006 |
| Popis: | Aims We sought to evaluate the prognostic values of B-type natriuretic peptide (BNP) after acute myocardium infarction. Methods We have measured BNP in frozen plasma specimens obtained 39 ± 17 h, after the onset of ischemic symptoms in 86 patients who had myocardium infarction. Death and severe cardiac events were recorded for a 24 months. Results Adjusted odds ratios (ORs) for death at BNP > 306 pg/ml was 13.26 (95% confidence interval: 2.41–72.7) at 2 years. BNP > 306 pg/mL has a sensitivity of 86.3%, specificity of 81.8%, positive predictive value of 82.6% and negative predictive value of 85.7% in predicting death or severe cardiac event 2 years after myocardium infarction. BNP provides a better risk stratification concerning mortality after myocardium infarction. Conclusion A single measurement of BNP, obtained in the first 3 days after the onset of myocardium infarction, provides predictive information for use in risk stratification across the spectrum of acute coronary syndromes. |
| Databáze: | OpenAIRE |
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