Relation of Chlamydia pneumoniae serology to mortality and incidence of ischaemic heart disease over 13 years in the Caerphilly prospective heart disease study Commentary: Chlamydia pneumoniae infection and ischaemic heart disease
| Autor: | D. P Strachan, D. Carrington, M. A Mendall, L. Ballam, J. Morris, B. K Butland, P. M Sweetnam, P. C Elwood, R. R West |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Chlamydia Heart disease business.industry Incidence (epidemiology) General Engineering Case-control study General Medicine medicine.disease_cause medicine.disease Serology Chlamydophila pneumoniae Internal medicine Immunology General Earth and Planetary Sciences Medicine business Prospective cohort study General Environmental Science Cohort study |
| Zdroj: | BMJ. 318:1035-1040 |
| ISSN: | 1468-5833 0959-8138 |
| Popis: | Objectives: To investigate the effect of Chlamydia pneumoniae infection on future development of ischaemic heart disease and mortality. Design: Prospective longitudinal study. Setting: Caerphilly, South Wales. Subjects: Plasma specimens were collected during 1979-83 from 1773 men aged 45-59 years. These were tested for IgG and IgA antibodies to C pneumoniae (TW183) by microimmunofluorescence. Outcome measures: 13 year mortality and incident ischaemic heart disease events were ascertained from death certificates, hospital records, and electrocardiographic changes at follow up every 4 to 5 years. Results: 642 men (36.2%) had IgG antibodies at a titre of Conclusion: This is the first prospective demonstration of an association between IgA antibodies to C pneumoniae, a putative marker of chronic infection, and subsequent risk of death from ischaemic heart disease. In contrast to earlier case-control studies, IgG antibodies were not associated with either prevalent or incident ischaemic heart disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|